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Carcinogenesis In the lifetime carcinogenicity review carried out in B6C3F1 mice, methylphenidate caused an increase in hepatocellular adenomas, As well as in males only, a rise in hepatoblastomas in a each day dose of roughly sixty mg/kg/day. This dose is about 2 situations the MRHD of sixty mg/working day supplied to kids on mg/m2 basis.The same